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Diabetes

Diabetes explained: types (1, 2, gestational), symptoms, diagnosis tests (A1C and glucose), treatment options, complications, prevention, and when to seek urgent care—Nelson’s Medical.

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Diabetes

Diabetes explained: types (1, 2, gestational), symptoms, diagnosis tests (A1C and glucose), treatment options, complications, prevention, and when to seek urgent care—Nelson’s Medical.

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Important notice: This content is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and treatment.

At a glance

  • Diabetes = high blood sugar over time.
  • Caused by insulin deficiency, insulin resistance, or both.
  • Management reduces emergency risk now and complications later.

Most common types

  • Type 1: little/no insulin (autoimmune).
  • Type 2: insulin resistance + reduced insulin over time.
  • Gestational: pregnancy-related insulin resistance.

Urgent warning signs

Seek urgent help for persistent vomiting, severe abdominal pain, trouble breathing, confusion, or extreme drowsiness.

What diabetes is (and what it isn’t)

Diabetes mellitus is a condition where blood glucose (blood sugar) stays higher than normal. Glucose is a key fuel for the body. The pancreas makes insulin, a hormone that helps move glucose from the bloodstream into cells.

Diabetes happens when the body doesn’t make enough insulin, can’t use insulin effectively (called insulin resistance), or both. Over time, high blood sugar can damage blood vessels and nerves, raising the risk of heart disease, stroke, kidney disease, vision problems, and nerve damage—especially in the feet.

Plain-language core

Diabetes is a long-term blood sugar regulation problem. Treatment is about safer ranges and fewer dangerous swings—not perfection.

Diabetes is not a moral failure and it isn’t simply caused by eating sugar. Food patterns matter, but genetics, hormones, pregnancy, medications, sleep, stress, and other health factors also shape risk and control.

Types of diabetes

Type 1 diabetes

Usually autoimmune damage to insulin-producing cells → little or no insulin. Type 1 can begin in childhood or adulthood. Insulin therapy is required.

Type 2 diabetes

Insulin resistance plus reduced insulin production over time. Often gradual onset, and symptoms may be mild or absent early. Treatment includes lifestyle changes, medications, and sometimes insulin.

Gestational diabetes

Develops during pregnancy due to increased insulin resistance. Usually improves after delivery but increases future type 2 risk.

Prediabetes

Blood sugar higher than normal but below diabetes range. It’s a warning sign—many people reduce progression risk with targeted changes.

Symptoms and warning signs

Some people—especially with early type 2—may have few or no symptoms. Common signs include:

Common symptoms

  • Increased thirst
  • Frequent urination
  • Fatigue
  • Blurred vision
  • Increased hunger
  • Slow healing cuts or frequent infections
  • Unexplained weight loss (more common in type 1)

Danger signs (seek urgent care)

  • Persistent vomiting
  • Severe abdominal pain
  • Rapid or deep breathing
  • Fruity-smelling breath
  • Severe weakness or dehydration
  • Confusion or extreme drowsiness

These may indicate emergencies like DKA or HHS.

Diagnosis: A1C and glucose tests

Diabetes is diagnosed with blood tests. Common tests include:

A1C

Estimates average blood sugar over ~2–3 months. Useful for long-term patterns.

Fasting plasma glucose

Measures blood sugar after at least 8 hours without eating.

OGTT

Measures blood sugar response after a glucose drink. Often used in pregnancy.

Random plasma glucose

Sometimes used when symptoms are present and glucose is clearly elevated.

Note: A1C can be less accurate with certain anemias, hemoglobin variants, recent transfusion, or some kidney disease. Clinicians may rely more on glucose-based tests in those cases.

Treatment: lifestyle, medications, insulin

Lifestyle foundations

  • Nutrition: minimally processed foods, adequate protein/fiber, consistent carbohydrate patterns.
  • Activity: aerobic + resistance training improves insulin sensitivity; post-meal walks can help reduce spikes.
  • Sleep: poor sleep can increase insulin resistance.
  • Stress: stress hormones can raise glucose; coping strategies matter.
  • Weight management (when appropriate): modest loss can improve insulin sensitivity for many with type 2.

Medications

Medications are chosen based on diabetes type, glucose patterns, kidney and heart health, risk of low blood sugar, side effects, cost, and personal preferences. Different classes work in different ways.

Insulin therapy

Insulin is required for type 1 diabetes and may be needed for type 2 in certain situations (illness, pregnancy, surgery, or later stages). Needing insulin is not a failure—it can be the safest tool to protect the body.

Monitoring and daily patterns

Monitoring helps you connect cause-and-effect: meals, activity, stress, sleep, and medication timing. The goal is learning patterns and reducing dangerous swings.

Fingerstick meter

Targeted checks: fasting, before/after meals, bedtime, symptoms.

CGM

Trends all day/night + alerts for highs and lows.

A1C

Long-term average marker; helps estimate overall control.

Low blood sugar (hypoglycemia)

Hypoglycemia is more likely in people who use insulin or certain medications. Symptoms can include shakiness, sweating, fast heartbeat, hunger, irritability, headache, dizziness, or confusion.

Emergency: If someone cannot safely swallow, has a seizure, or loses consciousness, call emergency services immediately.

High blood sugar (hyperglycemia)

Hyperglycemia can cause thirst, frequent urination, fatigue, and blurred vision. It may worsen during illness, stress, missed medications, or changes in eating/activity.

Seek urgent evaluation if high blood sugar is paired with persistent vomiting, dehydration, trouble breathing, confusion, or severe weakness.

Complications and prevention

Over time, uncontrolled diabetes can injure both large and small blood vessels and nerves. Preventive care and steady control reduce risk.

Common complications

  • Heart disease and stroke
  • Kidney disease
  • Eye disease (retinopathy)
  • Nerve damage (neuropathy)
  • Foot ulcers and slow wound healing

High-impact prevention

  • Safer glucose ranges with a sustainable plan
  • Blood pressure and cholesterol management as recommended
  • Avoid smoking/vaping
  • Routine eye, kidney, and foot screening
  • Stay current on vaccinations

Daily life: food, activity, sleep, and stress

Food without the chaos

There is no single “perfect diabetes diet.” Sustainable patterns beat extreme rules. Many people do well with balanced meals, consistent carbohydrates, more fiber, and fewer ultra-processed foods. Monitoring can help identify personal triggers and patterns.

Movement as glucose medicine

Muscles use glucose efficiently, especially during and after activity. Regular movement improves insulin sensitivity. If you use insulin or medications that can cause lows, ask your clinician about safe exercise planning.

Sleep and stress

Poor sleep and chronic stress can raise blood sugar via hormones. Improving sleep consistency and adding stress tools (breathing, counseling, journaling, social support) can improve control over time.

Special situations

Pregnancy (gestational diabetes)

Management focuses on safer glucose ranges for pregnancy, often with a nutrition plan and monitoring. Some people need medication or insulin. After delivery, follow-up screening is important because long-term diabetes risk is higher.

Illness (“sick days”)

Illness can raise blood sugar even when eating less. Many people benefit from a sick-day plan: hydration, more frequent checks, and medication guidance. Some may be advised to check ketones during illness or persistent highs.

When to seek urgent care

Call your clinician (same day/next day)

  • Repeated high readings despite your plan
  • Frequent low blood sugar episodes
  • New numbness, foot sores, or vision changes
  • Medication side effects or trouble affording meds
  • Pregnancy or major life changes requiring plan updates

Seek urgent/emergency care now

  • Severe confusion, fainting, seizure, or inability to stay awake
  • Inability to safely swallow (possible severe low)
  • Persistent vomiting, severe abdominal pain, rapid/deep breathing, fruity breath
  • Suspected DKA/HHS, severe dehydration, trouble breathing
  • Chest pain or stroke symptoms

Common myths

“If I need insulin, I failed.”

Insulin is a tool. Diabetes can progress. Using insulin can protect organs and reduce risk.

“Only sugar causes diabetes.”

Risk is shaped by genetics, hormones, medications, sleep, stress, and lifestyle patterns.

“I’ll feel it if my sugar is high.”

Many people don’t. Monitoring and lab tests catch problems early.

“Carbs are evil forever.”

Carb awareness matters, but sustainable patterns beat extreme restrictions.

Quick FAQ

Can type 2 diabetes be prevented?

Many people reduce risk through healthier eating patterns, regular activity, weight management, and adequate sleep. Prediabetes is a key opportunity for prevention.

Can diabetes be cured?

Diabetes is usually not “cured,” but it can be well controlled. Some people with type 2 diabetes achieve remission with major lifestyle changes and/or bariatric surgery, but ongoing monitoring remains important.

What should I track day to day?

Many people track glucose readings or CGM trends, medication timing, meals, activity, and sleep. The goal is learning patterns and preventing dangerous swings.

Nelson’s Medical supports evidence-based care and practical self-management. If your symptoms are severe or worsening, seek medical evaluation.

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Key Takeaways & Study Notes

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Diabetes Study Guide

Comprehensive medical student notes

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Educational use only. Diabetes care is individualized. For severe confusion, fainting, seizures, trouble breathing, persistent vomiting, or suspected DKA/HHS, seek emergency care.

10
Key Sections
4
Diabetes Types
3
Acute Emergencies
6
Treatment Pillars
1

Big Picture (High-Yield)

Core Definition

Diabetes mellitus = chronic dysregulation of blood glucose (hyperglycemia).

Hormone Action

  • ↘️ Insulin lowers blood glucose by moving glucose into cells and reducing liver glucose output.
  • ↗️ Glucagon raises blood glucose (mainly by increasing liver glucose release).

Pathogenesis

Damage over time comes from glucose toxicity + vascular inflammation → blood vessel and nerve injury.

Clinical Goals

  • Reduce short-term emergencies (severe highs/lows, DKA/HHS)
  • 🕒 Prevent long-term complications
2

Types & Mechanisms (Know the "Why")

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Type 1 Diabetes

  • Autoimmune β-cell destruction → absolute insulin deficiency
  • Can occur at any age
  • ⚠️ High risk for ketosis/DKA if insulin interrupted
  • 💉 Insulin required
🔬

Type 2 Diabetes

  • Insulin resistance + progressive β-cell dysfunction
  • Often gradual onset; may be asymptomatic early
  • 💊 Management: lifestyle + oral/injectable meds ± insulin
🤰

Gestational Diabetes

  • Pregnancy hormones ↑ insulin resistance
  • ⚠️ Raises risk of pregnancy complications if uncontrolled
  • ↗️ Raises future type 2 diabetes risk
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Prediabetes

  • Glucose higher than normal but not in diabetes range
  • 🎯 Important risk state: intervention can reduce progression

Secondary diabetes can be medication-related (e.g., steroids), pancreatic disease, endocrinopathies, or rare genetic syndromes. When the pattern doesn't fit, clinicians may test further to clarify the type.

3

Symptoms (Recognize Patterns)

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Hyperglycemia (High Blood Sugar)

  • 1 Polydipsia (increased thirst), polyuria (frequent urination)
  • 2 Fatigue, blurred vision
  • 3 Slow wound healing, recurrent infections
  • 4 Unexplained weight loss (more common in type 1)
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Hypoglycemia (Low Blood Sugar)

Common with insulin/some meds
  • 1 Shakiness, sweating, palpitations, hunger
  • 2 Irritability, headache, dizziness
  • 3 Confusion, behavior change
  • ⚠️ Severe: Seizure, loss of consciousness (medical emergency)
4

Diagnosis (Memorize the Criteria)

Note: Diabetes is diagnosed using blood tests. If results are borderline or unexpected, clinicians may repeat testing and interpret in context.

Test Normal Prediabetes Diabetes
A1C < 5.7% 5.7%–6.4% ≥ 6.5%
Fasting Plasma Glucose (FPG) < 100 mg/dL 100–125 mg/dL ≥ 126 mg/dL
2-hour OGTT ≤ 140 mg/dL 140–199 mg/dL ≥ 200 mg/dL
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Clinical pearl: A random plasma glucose ≥ 200 mg/dL with classic symptoms can also support a diabetes diagnosis. (Confirmatory testing is common when symptoms aren't clear.)

A1C can be less reliable with certain anemias, hemoglobin variants, recent transfusion, or kidney disease—clinicians may use glucose-based tests instead.

5

Monitoring (How Clinicians Track Control)

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A1C

"Big picture" average over ~2–3 months (not a daily tool).

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SMBG (Fingerstick)

Checks at targeted times (fasting, pre-/post-meal, bedtime, symptoms).

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CGM

Continuous trends + alerts for highs/lows; helps identify patterns and overnight events.

Focus on patterns (timing, meals, activity, meds) rather than single readings.

6

Treatment Pillars (Framework)

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Education & Self-Management

Recognizing highs/lows, medication timing, sick-day planning, safety skills.

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Nutrition Pattern

Consistent carbohydrate awareness, more fiber/protein, fewer ultra-processed foods.

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Physical Activity

Aerobic + resistance training improves insulin sensitivity; even short walks help.

😴

Sleep & Stress

Both influence hormones that affect glucose; improving them can improve control.

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Medications

Selected based on glucose pattern, comorbidities, safety, cost, and preferences.

Medication Categories (Mechanism-Level)

Metformin First-line

Improves insulin sensitivity; reduces liver glucose output.

GLP-1 Receptor Agonists Cardio/Renal benefit

Enhance glucose-dependent insulin secretion; increase satiety; slow gastric emptying.

SGLT2 Inhibitors Kidney protection

Increase urinary glucose excretion; important kidney/volume considerations.

DPP-4 Inhibitors Weight-neutral

Modest glucose lowering; weight-neutral for many.

Sulfonylureas Hypoglycemia risk

Increase insulin release; higher hypoglycemia risk.

Insulin Required in type 1

Required in type 1; sometimes needed in type 2; regimens vary (basal, bolus, pump).

💪

Stigma-buster: Needing insulin is not a "failure." It can be the safest tool when the pancreas can't meet demand.

7

Acute Emergencies (Must-Know)

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Severe Hypoglycemia

Neuro symptoms:

Confusion, inability to safely swallow, seizure, loss of consciousness.

Action:

Emergency response; use prescribed rescue treatments (e.g., glucagon) if trained/available.

🔥

Diabetic Ketoacidosis (DKA)

Pathophysiology:

Insulin deficiency → fat breakdown → ketones → metabolic acidosis.

Clinical clues:

Abdominal pain, vomiting, dehydration, rapid/deep breathing, fruity breath.

Action:

Emergency care.

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Hyperosmolar Hyperglycemic State (HHS)

Presentation:

Usually type 2; extremely high glucose + severe dehydration.

Clinical clues:

Profound weakness, confusion, severe dehydration, sometimes seizures.

Action:

Emergency care.

Illness can raise glucose even when eating less. Many patients benefit from a clinician-provided sick-day plan.

8

Chronic Complications (and Prevention)

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Microvascular

  • 👁️

    Retinopathy

    Vision loss risk

  • 🫀

    Nephropathy

    Kidney damage

  • 🦶

    Neuropathy

    Numbness/pain; foot injury risk

❤️

Macrovascular

  • 🫀

    Coronary Artery Disease

  • 🧠

    Stroke

  • 🦵

    Peripheral Arterial Disease

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Prevention Themes

  • 📊 Glucose control + fewer extreme swings
  • 💓 Blood pressure and lipid management
  • 🚭 Smoking cessation
  • 👁️ Routine screening (eyes, kidneys, feet)
9

Exam Pearls (Quick Hits)

Type 1 vs Type 2

  • Type 1: autoimmune + ketosis risk; insulin interruption = rapid danger
  • Type 2: insulin resistance; may be silent for years → screening matters
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Key Reminders

  • A1C is convenient, but not perfect (conditions affecting RBCs can distort it)
  • Many complications are preventable with systematic care
10

Mini Self-Check (Quiz Prompts)

  1. 1

    Explain (in 1–2 sentences) the pathophysiology difference between type 1 and type 2 diabetes.

    Answer space...

  2. 2

    List 5 classic hyperglycemia symptoms and 5 hypoglycemia symptoms.

    Answer space...

  3. 3

    State the diagnostic cutoffs for A1C, fasting glucose, and 2-hour OGTT.

    Answer space...

  4. 4

    Compare DKA vs HHS (who gets it, key mechanism, why dangerous).

    Answer space...

  5. 5

    Name 3 microvascular and 3 macrovascular complications.

    Answer space...

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Practice tip: Don't memorize diabetes as a list—memorize it as a system (insulin production, insulin sensitivity, glucose input/output, and risk over time).

Medical Education Resource • Version 1.0